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2.2 Iron homeostasis As an essential redox-active metal for neuronal activity and normal physiological function, iron plays a vital role in energy metabolism, biosynthesis, neurotransmission, and myelination (Ward et al., 2014), which bind to the iron response element (IRE) of iron-metabolizing genes and regulate their expression, leading to changes in cellular iron metabolism (Wang and Pantopoulos, 2011

Indeed, Figures 2E,F show that creatine diet supplementation also significantly decreased H 2 O 2 production and restored aconitase activity that were altered by pravastatin treatment ( Figure 3 )

Cardiovascular risk is elevated in psoriasis patients due to chronic systemic inflammation

doi:10.1093/cid/cir257

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